Dissecting the Anti-Desmoglein Autoreactive B Cell Repertoire in Pemphigus Vulgaris Patients

Patients B Cell Repertoire in Pemphigus Vulgaris Dissecting the Anti-Desmoglein Autoreactive

Pemphigus Vulgaris (PV) and Healthy Responses to Desmoglein 3 in Patients with Dichotomy of Autoreactive Th1 and Th2 Cell

Persistence of Anti-Desmoglein 3 IgG+ B-Cell Clones in Pemphigus Patients Over Years

Pemphigus vulgaris (PV) is a prototypic tissue-specific autoantibody-mediated disease, in which anti-desmoglein 3 (Dsg3) IgG autoantibodies cause life-threatening blistering. We characterized the autoimmune B-cell response over 14 patient years in two patients with active and relapsing disease, then in one of these patients after long-term remission induced by multiple courses of rituximab (ant...

Pathogenic activity of circulating anti-desmoglein-3 autoantibodies isolated from pemphigus vulgaris patients

INTRODUCTION There are scarce data on immunochemical properties of pemphigus antibodies detected in clinical remission in pemphigus vulgaris (PV) patients. The aim of the study was to compare biological activity of anti-Dsg3 autoantibodies purified from the sera of PV patients in active stage and in clinical remission. MATERIAL AND METHODS The effect of purified antibodies on expression of pr...

Healthy Individuals in Patients with Pemphigus Vulgaris and T Cell Recognition of Desmoglein 3 Peptides